The Second International Symposium for Chinese Medicinal Chemists

Introduction
Conference Organization
Scientific Program (speakers)
Call for Contributions
General Information
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Scientific Program

The symposium will include plenary and invited lectures, oral and poster contributions, dealing broadly with topics in the following areas:

Bioorganic & medicinal chemistry and enzymatic reactions
Bioinformatics and computer-aid drug design
Combinatorial & solid-phase chemistry and high throughput screening
Discovery of novel molecular targets for drug action
Natural products and TCM as leads for drug discovery
New synthetic methodology and chirotechnology

Confirmed Speakers (as 6 December 2002)

Plenary Speakers

Prof. Hung-wen Liu (University of Texas, Austin)

Studies of UDP-galactopyranose mutase from Escherichia coli. An unusual role of reduced FAD in its catalysis

Prof. Tsann-Long Su (Institute of Biomedical Sciences, Academia Sinica, Taipei)

Development of DNA topoisomerase II-mediated anticancer agent: AHMA derivatives

Prof. Li-He Zhang (Peking University, Beijing)

Chemical syntheses and calcium release activities of N-1-glycosyl substituted cADPR mimics

Invited Speakers (updated)

Dr. Jianming Bao (Merck & Co., Inc., Rahway)

Pyrrolidine modulators of chemokine receptor activity

Prof. Ji-Wang Chern (National Taiwan University, Taipei)

Design and synthesis of potential DNA double and triple helices stabilizing agents

Dr. Der-Hang Chin (National Chung-Hsing University, Taichung)

The action of apoprotein in the antitumor antibiotic neocarzinostatin

Dr. Daniel T. W. Chu (Chiron Corporation, Emeryville)

Recent advance in macrolide antibiotic research

Prof. Zhongwu Guo (Case Western Reserve University, Cleveland)

Glycopeptide synthesis with free oligosaccharides as phase tags

Prof. Zong-Ru Guo (Institute of Materia Medica, CAMS, Beijing)

Design and synthesis of anti-diabetics based on PPAR-gamma structure and virtual screening of focused library

Prof. Xiao-Jiang Hao (Kunming Institute of Botany, CAS, Kunming)

Bioactive compounds from Chinese medicinal plants

Prof. Richard K. Haynes (The Hong Kong University of Science and Technology, Hong Kong)

Hyperactive peroxidic antimalarials and questions on mechanism of action

Prof. Ziwei Huang (University of Illinois at Urbana-Champaign, Urbana)

Protein-protein interactions: Mechanisms, medicinal chemistry, and implications for post-genomic drug discovery

Prof. Hua-Liang Jiang (Shanghai Institute of Materia Medica, CAS, Shanghai)

Aspects of virtual screening in the cycle of drug discovery: Successful stories, prospects and challenges

Prof. Xiaoyu Li (Shanghai Institute of Materia Medica, CAS, Shanghai)

Immunomodulating natural products from Chinese herbs

Prof. Chun-Hung Lin (Institute of Biological Chemistry, Academia Sinica, Taipei)

Synthesis of bioactive carbohydrates by glycosidic bond formation

Prof. Guo-Qiang Lin (Shanghai Institute of Organic Chemistry, CAS, Shanghai)

Recent development in the carbon-carbon bond formation: Learn something from natural products

Dr. Kun Liu (Merck & Co., Inc., Rahway)

Small molecule insulin mimetics with potential utilities as anti-diabetic as well as anti-obesity therapies

Prof. Dawei Ma (Shanghai Institute of Organic Chemistry, CAS, Shanghai)

Design and synthesis of matrix metalloproteinase inhibitors

Prof. Dehua Pei (The Ohio State University, Columbus)

Enzymes for posttranslational protein modification as novel drug targets

Prof. Ben Shen (University of Wisconsin-Madison, Madison)

Natural product biosynthesis and prospects of engineering microorganisms for chemical structural diversity

Prof. Cherng-Chyi Tzeng (Kaohsiung Medical University, Kaohsiung)

Synthesis and anticancer evaluation of furoquinolines

Prof. Lai-Xi Wang (Institute of Human Virology, University of Maryland, Baltimore)

Bioorganic approaches to an effective HIV vaccine

Prof. Peng George Wang (Wayne State University, Detroit)

Carbohydrate-based drug development

Prof. Yan-Guang Wang (Zhejiang University, Hangzhou)

Polymer-supported synthesis of heterocycles

Prof. Yun-Dong Wu (The Hong Kong University of Science and Technology, Hong Kong)

Theoretical study of secondary structures of peptides

Prof. Zhen Xi (Nankai University, Tianjin)

DNA recognition and damage by small molecules at bulge site

Dr. Xiao-Yi Xiao (Syrrx, Inc., San Diego)

High throughput crystallography and structure-based drug discovery

Dr. Jun Xu (Cheminformatics, Discovery Partners International, Inc., San Diego)

HTS data mining and virtual library analysis

Dr. Yao-Chang Xu (Lilly Research Laboratories, Lilly Corporate Center, Indianapolis)

From an idea to a clinical candidate: A search for new treatment of depression using selective 5-HT1A receptor antagonist

Prof. Michael M. Yang (City University of Hong Kong, Hong Kong)

Integration of functional genomics and cell-based assays for drug discovery from traditional Chinese medicine

Prof. Zhen Yang (Peking University, Beijing)

Diversity-oriented synthesis and branched reaction pathway applied to natural product-like compounds

Dr. Tao Ye (The Hong Kong Polytechnic University, Hong Kong)

Studies toward the total synthesis of pharmaceutically active marine natural products

Prof. Biliang Zhang (UMASS Medical School, Worcester)

High-throughput synthesis for anti-HIV and anticancer drug discovery

Prof. Yi-Hua Zhang (China Pharmaceutical University, Nanjing)

Design, synthesis and anti-inflammatory activity of a-substituted p-(methanesulfonylphenyl)propenoic acid and related compounds

Dr. Jieping Zhu (Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette)

Development of novel multicomponent domino process for heterocycle synthesis

Preliminary Program

	Saturday 28 December	Sunday 29 December	Monday 30 December	Tuesday 31 December
9:00-10:15		Opening ceremony Plenary Lecture	Plenary Lecture Invited Lecture	Session 13 Invited Lectures
10:15-10:30		Tea break	Tea break	Tea break
10:30-12:10		Sessions 1 and 2 Invited Lectures Oral Presentations	Sessions 7 and 8 Invited Lectures Oral Presentations	Session 14 Invited Lectures Closing ceremony
12:10-14:00		Lunch	Lunch	Lunch
14:00-15:30	Registration 14:00-21:00	Sessions 3 and 4 Invited Lectures	Sessions 9 and 10 Invited Lectures	Optional tours 13:00-17:00
15:30-15:50		Tea break	Tea break
15:50-17:30		Sessions 5 and 6 Oral Presentations	Sessions 11 and 12 Oral Presentations	End of symposium
18:00-19:30	Welcome reception 18:30-21:00	Dinner	Banquet 18:00-20:00
19:30-21:30		Poster Presentations

Additional parallel sessions may be added at a later stage.

Updated on 6 December 2002 by Wei-Min Dai